"Craig called me and said “What about Kristen?” And I said, “Oh, duh.” To be honest, when we were doing this was during the time when Bridesmaids came out, when the part of Maggie fell through and we had to find another Maggie. I was like, “Kristen is shooting all these other movies, she’s not gonna be available.” It was very sweet, Kristen called me and said, “Hey, I read Skeleton Twins, I really like it. I’d like to do it, but only if you’ll have me.” I was like, “Are you joking? Of course.” It didn’t even dawn on me until later that, oh yeah, we have this brother-sister relationship…”

- Bill Hader on casting Kristen Wiig